Posted on 2025/12/13
Bioinformatics Engineer (Spatial & AI Training)
Metric Bio
San Francisco, CA, United States
Qualifications
- End-to-end analysis of one or more spatial platforms: Seeker/Trekker (Slide-seq), MERFISH, DBiT-seq, Xenium, Visium, Stereo-seq, GeoMx, CosMx, or similar assays
- 3+ datasets completed from raw data final biological insight for publications or real industry decisions
- Working understanding of kit-specific numerical sanity checks, eg
- QC thresholds, and when results deviate from expectation
- Familiarity with key spatial computational tools (cell segmentation, cell typing, ligand–receptor analysis)
- Strong grasp of experimental design, hypothesis generation, and interpreting spatial-omics papers
- Working knowledge of statistical inference (tests, confidence intervals, estimators)
- Working knowledge of high-dimensional algorithms (PCA, neighborhood graphs, UMAP)
Responsibilities
- Your job is to generate the high-signal training data that powers these agentic biology systems
Full Description
Bioinformatics Engineering Consultant — Spatial & AI Training
(1099 Contract, Onsite SF)(FTE conversion is certainly on the table for top performers)
We're working with a world-class engineering team building biological LLMs that can execute pipelines, interpret results, and reason about data.
These models only become reliable when trained on real expert judgment: workflows, QC thresholds, and failure diagnoses.
Your job is to generate the high-signal training data that powers these agentic biology systems.
You MUST bring hands-on experience with:
• End-to-end analysis of one or more spatial platforms: Seeker/Trekker (Slide-seq), MERFISH, DBiT-seq, Xenium, Visium, Stereo-seq, GeoMx, CosMx, or similar assays.
• 3+ datasets completed from raw data final biological insight for publications or real industry decisions.
• Working understanding of kit-specific numerical sanity checks, eg. QC thresholds, and when results deviate from expectation.
• Familiarity with key spatial computational tools (cell segmentation, cell typing, ligand–receptor analysis).
• Strong grasp of experimental design, hypothesis generation, and interpreting spatial-omics papers.
• Working knowledge of statistical inference (tests, confidence intervals, estimators).
• Working knowledge of high-dimensional algorithms (PCA, neighborhood graphs, UMAP).
Why the Bar Is High
The impact is high.
If this describes your background, we want to work with you.

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