Research Scientist (Analytical / LC-MS / Oligonucleotides

Qualifications

• The ideal candidate will have strong laboratory skills, research experience, and the ability to conduct experiments, analyze data, and support product development initiatives
• MS or BS with 3+ years of industrial experience
• Strong knowledge of mass spectrometry and purification techniques
• Experience with analytical techniques e.g. RP-UPLC, SAX-HPLC, LC-MS and data interpretation
• Strong background in the analytical development of methods for the analysis of oligonucleotide therapeutics
• Experience with IP-RP-UHPLC and AX-HPLC analytical techniques using Ag-ilent, Waters and/or Thermo UHPLC’s and associated software
• In depth knowledge of GLP/GMP’s in a pharmaceutical environment
• Must possess excellent writing and communication skills and a demonstrated ability to work independently and with cross-functional teams

Responsibilities

• We are seeking a dedicated and analytical Associate Scientist II to join our research team and contribute to innovative scientific projects
• Primary responsibility to provide analytical lab support for Oligonucleotide early phase pipeline
• Development of robust LC/MS, IPRP and SAX analytical methods for analysis and purification of highly modified oligonucleotide drug substances
• Prepare analytical samples, analyze and process data, primarily by UPLC, LC-MS
• Operate, maintain and troubleshoot lab instruments
• Conduct and help design unique experiments to help in characterization of highly modified oligonucleotides and sgRNA
• Keep accurate records of the experiments and summarize the results in well communicated presentations or written reports
• Purification, deprotection, annealing and lyophilization of oligonucleotides to support all disease programs
• Oligonucleotide synthesis
• Possess excellent written and verbal communication skills
• Conduct laboratory work in an efficient manner that ensures a safe working environment

Full Description

🌟 We're Hiring: Associate Scientist II! 🌟

We are seeking a dedicated and analytical Associate Scientist II to join our research team and contribute to innovative scientific projects. The ideal candidate will have strong laboratory skills, research experience, and the ability to conduct experiments, analyze data, and support product development initiatives.

📍 Location: Lexington, MA

What You'll Do

• Primary responsibility to provide analytical lab support for Oligonucleotide early phase pipeline

• Development of robust LC/MS, IPRP and SAX analytical methods for analysis and purification of highly modified oligonucleotide drug substances.

• Prepare analytical samples, analyze and process data, primarily by UPLC, LC-MS

• Operate, maintain and troubleshoot lab instruments

• Conduct and help design unique experiments to help in characterization of highly modified oligonucleotides and sgRNA

• Keep accurate records of the experiments and summarize the results in well communicated presentations or written reports

• Purification, deprotection, annealing and lyophilization of oligonucleotides to support all disease programs

• Oligonucleotide synthesis

• Possess excellent written and verbal communication skills

• Conduct laboratory work in an efficient manner that ensures a safe working environment

What We're Looking For

• MS or BS with 3+ years of industrial experience

• Strong knowledge of mass spectrometry and purification techniques

• Experience with analytical techniques e.g. RP-UPLC, SAX-HPLC, LC-MS and data interpretation

• Experience with waters LC/MS instruments preferred

• Experience with purification and LC/MS analysis of sgRNA highly preferred

• Strong background in the analytical development of methods for the analysis of oligonucleotide therapeutics

• Experience with IP-RP-UHPLC and AX-HPLC analytical techniques using Ag-ilent, Waters and/or Thermo UHPLC’s and associated software

• In depth knowledge of GLP/GMP’s in a pharmaceutical environment

• Must possess excellent writing and communication skills and a demonstrated ability to work independently and with cross-functional teams

Ready to advance your scientific career? 🚀 Apply now and let's innovate together!